The common approach of intensive blood glucose control to achieve low blood sugar goals in type 2 diabetes may increase the risk of mortality, according to a study by Cardiff University.
Looking at routine data from more than 300,000 people in the UK, collected between 2004 and 2015, researchers found that lower levels of glycated hemoglobin - generally considered a good control of diabetes - were associated with an increased risk of death. especially in conjunction with intensive treatments that could cause hypoglycaemia.
Professor Craig Currie of the Cardiff University School of Medicine said, "Therapeutic guidelines generally recommend therapeutic strategies aimed at reducing glycemic control, being understood that it reduces the risk of macrovascular complications such as coronary heart disease and stroke. this belief, our results convincingly show that there is an association with an increased risk of mortality and what is considered a good control of blood glucose, or low HbA1c. "
The results of the study also suggest that neither randomized trials nor observational studies have been able to demonstrate a consistent pattern of association between blood glucose control levels and blood glucose levels. undesirable results, without any explanation as to why. Thus, the optimal target for glucose control in patients with type 2 diabetes remains unclear. In addition, the mortality profile versus glycemic control was different for different types of diabetes medications. The biggest concern was the increased risk of death in people with "good control" of type 2 diabetes treated with insulin and other hypoglycemic agents that induce hypoglycemia.
Professor Currie said, "Serious questions remain as to the safety of certain hypoglycemic drugs, as scientific evidence and differing opinions are largely ignored."
Source:
http://www.cardiff.ac.uk/news/view/1004909-good-glucose-could-be-bad-in-type-2 -diabetes
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